Endocrine Abstracts

Background: Mortality and morbidity after acute myocardial infarction (AMI) remain high even when myocardial reperfusion is successful. Thus, additional approaches are warranted. Erythropoietin (EPO) was found to be a cytoprotective molecule that might represent a novel strategy to limit the infarct size.Aim of the work: To investigate serum erythropoietin level and its relation to infarct size in Egyptian patients with AMI.Methods...

Background: Many cellular, preclinical and observational studies support a role for vitamin D (VD) in the pathogenesis of type 2 diabetes. VD is suggested to be an inhibitor of angiogenesis. A growing body of evidence suggests an association between VD inadequacy and diabetic retinopathy.Objective: To study the relation between 25 (OH) vitamin D level and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus and to evaluate for any relation...

Introduction: Gestational diabetes mellitus complicates up to 14% of pregnancies worldwide. Gestational diabetes mellitus women are more frequently affected by changes in bone turnover during pregnancy. Osteocalcin, ostoblast derived protein is suspected to be involved in the regulation of glucose and fat metabolism.Aim of the work: is to study serum osteocalcin levels in women with gestational diabetes mellitus.Subjects and method...

Background: Subclinical hypothyroidism is a common thyroid disorder. Although there is a recognized association between thyroid disease and diabetes mellitus, there is no definite answer as to whether screening for subclinical hypothyroidism is necessary in patients with type 2 diabetes.Objective: To evaluate the prevalence of subclinical hypothyroidism in women with type 2 diabetes in Egypt.Patients and methods: women with type 2 ...

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of β cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 d...

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of beta cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 dia...

Objectives: Vitamin D deficiency is rarely considered or treated in critically ill patients. Deficiency of 25-hydroxy vitamin D (25(OH) D) prior to hospital admission might be a significant predictor of short and long term all cause patient mortality in a critically ill patient. We aimed to investigate the prevalence of vitamin D deficiency in hospitalized patients and its relation to the length of stay and outcome of hospitalization.Methods: Prospective...

Background: Polycystic ovarian syndrome (PCO) is the most common endocrinopathy in adult women, and is emerging as a common cause of menstrual disturbance in the adolescent population. Insulin resistance, which is considered one of its underlying causes, has increased substantially in the past decade, putting more adolescent girls at risk for PCOS and its complications. Anti – Mullerian hormone (AMH) is secreted by the granulose...

Introduction: Irisin is a myokin secreted by myocytes responsible for transmission of signals from muscles to other body tissues. It improves systemic metabolism by increasing energy expenditure and has a significant influence on the body metabolism and thermogenesis. Thyroid disorders are characterized by a disrupted thermo-metabolic state and muscular damage, and the underlying mechanisms still not clear.Aim: To evaluate serum Irisin levels in patient ...

Type 1 diabetes mellitus (DM) is a multi system disease with both biochemical and anatomic/structural consequences. A number of components of the metabolic syndrome may be observed in patients with type 1 diabetes. It was suggested that treating obese adolescents with insulin resistance using metformin is an option for patients without response to traditional lifestyle change. It was reported that fetuin-A could inhibit insulin receptor tyrosine kinase activity and induced a l...